摘要:
采用干铺2烧结法制备了一种以二氧化锆(ZrO2 ) 为基体梯度复合羟基磷灰石( HAP) 的新型生物复合材料, 并对其力学性能、微观结构和生物相容性进行了研究。用扫描电镜(SEM) 、X 射线衍射仪(XRD) 、透射电镜( TEM) 和EDAX 能谱仪对粉体和复合材料进行分析。用复合材料的浸提液进行小鼠急性毒性试验、细胞毒性试验、体外溶血试验以及兔肌肉和骨内材料植入试验, 评价复合材料的生物相容性。研究结果表明, 复合材料的表面涂层厚度约80μm , 芯部基体组织与表面均匀过渡结合, 结合良好, 没有明显界面, 涂层结合强度为15. 1 MPa ,最大弯曲强度为1112. 24 MPa , KIC为7. 3～11. 4 MPa·m1/2 。其组织相容性好, 具有良好的骨传导作用, 促进骨组织生长, 是一种较理想的新型骨科植入材料。
Abstract:
A new bio-composite material , graded zirconia-hydroxyapatite composite Bioceramic , has been preparedby the dry-laying & sintering method , and it s mechanical properties , microst ructure and biocompatibility have beenstudied. The powders and the composite material were investigated using SEM , XRD , TEM and EDAX. To evaluate it s biocompatibility , the ext ract of the composite material was used to carry out a mouse acute toxicity test , a cytotoxicity test , an in vit ro hemolytic test , and a rabbit muscle and bone implantation experiment . The result s showthat the coating of the composite material is about 80μm thick , and is well bonded with the core mat rix without obvious interface. The bond st rength is 15. 1 MPa , the maximum flexural st rength is 1112. 24 MPa , and KIC is 7. 3～11. 4 MPa·m1/2 . The graded zirconia2hydroxyapatite composite bioceramic has excellent biocompatibilities and boneconductivities , which can promote the growing of bone issues , so it is an ideal bio-composite material for orthopaedicimplantation.
下载:
