Abstract: Water damage is the main form of asphalt mixture damage in humid and hot regions, which seriously affects the service quality of asphalt pavement. In order to clarify the evolution law of water damage of asphalt mixture in humid and hot regions and further improve the service performance of asphalt surface layer, the deterioration mechanism of moisture susceptibility of asphalt mixture caused by typical environmental factors in humid and hot regions such as dynamic water erosion, dry -wet cycle, salt erosion and their coupling effects, as well as the aging damage of asphalt caused by temperature-wet-ultraviolet irradiation were summarized. The occurrence and spatio-temporal evolution of asphalt mixture water damage in humid and hot regions were sorted out, and the improvement path of asphalt mixture moisture susceptibility was summarized from three aspects: functional admixture, aggregate and asphalt mixture composition design. On this basis, the prospects for the research on the moisture susceptibility of asphalt mixture in humid and hot regions are put forward. In the future, an evaluation system for the moisture susceptibility of asphalt mixture in humid and hot regions that is more in line with the actual working conditions should be established based on the multi-scale characterization of performance damage of asphalt/asphalt mixture under the action of multi-factors coupling, and an improvement method should be proposed, aiming to provide a useful reference for improving the stability and durability of asphalt surface in wider road regions under the background of Country with Strong Transportation Network.