多孔止血材料及其功能化设计策略

Functionalization Strategies for Porous Hemostatic Materials

  • 摘要: 创伤出血是临床急救与战场救治中的首要生命威胁,传统止血方式对深部创口效果有限且缺乏抗感染、促修复功能。多孔材料凭借高比表面积、可控孔径等优势成为研究热点,但单一结构难以满足多元化临床需求。为此,本文以功能化路径为核心,系统归纳本体功能型、物理负载型与化学接枝型三类策略:本体功能型依托本征活性实现快速止血,适用于不可压缩性创伤;物理负载型通过装载活性组分拓展抗菌、抗炎功能,适配感染性创面;化学接枝型通过共价锚定实现长效稳定功能,适用于复杂创面修复。三类策略的合理选择与协同应用,是实现从基材特性到临床需求精准匹配的关键,本文旨在为多孔止血材料的功能化设计与临床转化提供理论支撑。

     

    Abstract: Traumatic hemorrhage is the primary life-threatening factor in clinical emergency and battlefield treatment. Traditional hemostatic methods have limited efficacy on deep wounds and lack anti-infection and wound repair functions. Porous materials, with their high specific surface area and controllable pore size, have become a research hotspot. However, a single structure is difficult to meet the diverse clinical needs. Therefore, this paper, with functionalization as the core, systematically summarizes three strategies: intrinsic functional type, physical loading type, and chemical grafting type. The intrinsic functional type achieves rapid hemostasis through inherent activity and is suitable for non-compressible trauma. The physical loading type expands antibacterial and anti-inflammatory functions by loading active components and is suitable for infected wounds. The chemical grafting type realizes long-term stable functions through covalent anchoring and is suitable for complex wound repair. The rational selection and synergistic application of these three strategies are the key to precisely matching the material properties with clinical needs. This paper aims to provide theoretical support for the functional design and clinical transformation of porous hemostatic materials.

     

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