Abstract: The theoretical analysis of intimate contact and autohesion in molding process was carried out based on the research of composite winding process. The key process parameters affecting the quality of winding product, such as winding temperature, pressure and tension, were proposed. Based on Box-Behnken Design (BBD) theory of response surface methodology, the regression model of process parameters coupling on shear strength was established to optimize the interlaminar shear strength (ILSS). The reliability and effectiveness of regression model were verified through the test analysis such as residual, analysis of variance (ANVOA) and predicted versus actual. Furthermore, the optimal process parameters of winding process were obtained. Results illustrate that the winding products employing the optimum parameters bond in the highest strength with the interlaminar shear strength of 22.9 MPa.