Abstract: The interface is an important component and a weak link of composite materials/structures, and its mechanical properties have an important influence on the overall mechanical behaviors and functions of composites. Phenomenological interfacial constitutive laws have played an important role in solving various problems of materials and structures with interfaces, but they neglect the complex damage and failure processes at the mesoscopic scale. With the development and application of multiphase binders, important progress has been made in the field of multi-scale modeling and analysis of the interface. Firstly, interfaces are classified based on their geometrical configurations. Then, the fundamental problems of interface multiscale modeling are clarified, and modeling methods and key issues in interface multiscale modeling are summarized. Research progresses in both one-way and two-way multiscale modeling of the interface are reviewed. Finally, the problems that need to be further studied in interface multiscale modeling are prospected.