Abstract: Infected wounds seriously endanger the quality of life and even life and health of human beings, so the development of antimicrobial biomaterials with high efficiency and few side effects for the repair of infected wounds has broad market prospects. Two-dimensional transition metal carbide (MXene) is a new type of two-dimensional sheet material with excellent antibacterial properties, and its antibacterial mechanism mainly includes physical capture theory, infrared thermal effect, reactive oxygen species (ROS) generation theory, intercellular molecular leakage theory, etc., so MXene is expected to become a safer, effective and broad-spectrum antibacterial method. Compared with simple hydrogels, MXene composite hydrogels made of hydrogels encapsulated with MXene have better antibacterial, antioxidant properties and photothermal effects. In this paper, the antimicrobial mechanism of MXene was reviewed, and the researches on the repair of infected wounds by MXene composite hydrogels were comprehensively reviewed and summarized in recent years.