Abstract: With the rapid development of flexible pressure sensors in the fields of health detection, electronic skin and wearable electronic devices, the research on fabrication of high-performance flexible piezoresistive sensors has become prevalent. The performance of flexible pressure sensors can be optimized by nanomaterials because of their surface and interface effects, small size effects and macroscopic quantum tunneling effects. Nanomaterials based pressure sensor has the advantages of small size, wide detection range and high sensitivity. In this paper, the latest research progress of nanomaterials in flexible pressure sensors in recent years is reviewed.