Abstract: Taking the aluminum honeycomb sandwich panel as the object, through the low-speed drop weight test and the detailed simulation model including the panel, the adhesive layer and the honeycomb, the changes of low-speed impact response curve and damage mode under the influence of the honeycomb cell diameter, honeycomb wall thickness, panel thickness and punch radius parameters were studied. Three damage modes under the test conditions were determined: Core buckling, core shear and sandwich panel penetration, among which the core shear mode has better energy absorption distribution. The results show that the honeycomb cell diameter and the honeycomb wall thickness have similar effects on the impact response and damage mode. The increase of the panel thickness can greatly improve the impact resistance, and the size of the punch radius will significantly affect the damage mode. On this basis, the damage mode limit load formula related to the above parameters was established, and the corresponding damage mode diagram was drawn to provide a reference for the impact resistance design of aluminum honeycomb sandwich panels.