Abstract: A multiwalled carbon nanotubes (MWCNT)/natural rubber (NR) composite was prepared by two-roll method to achieve effective monitoring for the working performance of isolation bearings. The resistance-strain response behaviors of MWCNT/NR composites under constant strain and interval loading were studied. The results show that the stability, repeatability, monotonicity, symmetry and ‘shoulder peak’ effect of the resistance-strain response are depended on the constant strain loading. The variation amplitude of resistance tends to be stable with the increase of interval time, and the change of the amplitude can effectively be predicted via the theoretical model established. The piezoresistance behaviors for MWCNT/NR composite under different delamination forms show distinct characteristic, and the response mechanism is explained by Digimat and Workbench. A mathematical model that can completely characterize and predict the dynamic resistance-strain response was established and verified based on viscoelasticity of NR and conductivity network of MWCNT. The analytical results obtained by mathematical model are in good agreement with the experimental results, which lay a theoretical foundation for the industrial application of MWCNT/NR composites.