Abstract: In order to improve the bioactivity and osteogenic induction ability of porous hydroxyapatite (HA) biocomposites, porous ZnO-MgO/HA biocomposites with the mass fraction of ZnO 1.3wt% and MgO 8.4wt% were prepared by spark plasma sintering (SPS). The changes of microstructure, pore characteristics, in vitro mineralization and degradation behavior of porous composites at different sintering temperatures were studied. The effect of active ceramic phase addition on biological properties of porous HA materials in vitro and its mechanism were analyzed. The results show that the sintered porous composites are mainly composed of HA, ZnO and MgO phase. When the sintering temperature exceeds 950℃, a small amount of HA decomposition product Ca₃(PO₄)₂ phase appears. With the increase of sintering temperature, the porosity of porous composites decreases slowly, and the pore size decreases gradually. The porous composites have good osteoapatite formation ability in simulated body fluid at different sintering temperatures, and the degradation rate increases first and then decreases with the increase of sintering temperature. Comprehensive analysis shows that the porous ZnO-MgO/HA composites prepared at 950℃ have suitable pore characteristics (porosity (34.7±0.2)%, pore size between 150-400 μm accounts for 65.5%). Moreover, the porous HA material has excellent osteogenic ability, high degradation rate ((11.3±0.2)%), high cell proliferation rate ((91.7±2.1)%) and low cell apoptosis rate ((2.3±0.2)%), indicating that the addition of ZnO and MgO active ceramic phase significantly improves the osteogenic induction ability and biocompatibility of porous HA material.