Abstract: In order to explore the dynamic response and failure behaviors of fiber fabrics under blast load, quasi-static and high strain rate tensile tests were carried out on three plain fabrics, the mechanical properties of the fabrics were obtained, and the constitutive model of the fabric was established. Using the Arbitrary Lagrangian-Eulerian (ALE) algorithm, a numerical analysis model of the fabric under blast was established, and the dynamic response process and failure modes of the fabric under blast load were studied. The results were compared with the test to verify the validity of the model. The relationship between the deformation peak value and the scaled distance and the energy absorption of each fabric in the hybrid stacked fabrics were obtained that can evaluate the anti-blast ability of the fabrics. The results show that the three kinds of fabrics exhibit different degrees of strain rate sensitivity. The failure strain and ultimate strength of aramid and ultra-high molecular weight polyethylene (UHMWPE) fiber fabrics under high strain rate load increase with the increase of strain rate, showing obvious strain rate effect. The ultimate strength of carbon fiber fabric increases slightly, and the strain rate effect is not obvious. The numerical analysis has obtained the same failure modes of the fiber fabric as the test: Central hole and simply supported boundary tearing. In the studied working conditions, the deformation peak value of the fabric is inversely proportional to the proportional distance, and the back burst surface fabric fails when the deformation peak value exceeds 39 mm. The specific energy absorption of the UHMWPE fiber fabric reaches 24.7 J/g, which is 4.3 times and 8.5 times that of aramid fabric and carbon fiber fabric.