Abstract: Reverse osmosis is an operation that uses osmotic pressure as the driving force to separate solvent from solution. It has become the mainstream technology in the field of desalination due to its advantages of low energy consumption, low cost and environmental friendliness, leading the global seawater/brackish water desalination market. As the core of reverse osmosis technology, reverse osmosis membranes still have some problems of water flux, salt rejection and insufficient durability to meet the increasing demand. The development of mixed matrix reverse osmosis membranes based on inorganic nanomaterial has injected new vitality into solving this problem, and there have been many research reports. This paper reviewed the current research progress of inorganic nanohybrid matrix reverse osmosis membrane, focusing on the research status and progress, problems and challenges of zero-dimensional, one-dimensional and two-dimensional inorganic nanohybrid matrix and inorganic nanocomposite hybrid matrix reverse osmosis membranes. Finally, the future research directions of mixed matrix reverse osmosis membrane filled with inorganic nanomaterials were also analyzed and prospected.