Abstract: The main reason for the aseptic loosening of the implant is the fretting wear between the implant and the bone tissue. A carbon fiber (CF) reinforced polyetheretherketone (PEEK) composite material was prepared by a layered method. Under simulated body temperature of 37℃ and simulated body fluid (SBF) lubrication conditions, the basic mechanical properties and the fretting tribological properties of the section of CF/PEEK composites were explored. By changing the normal load and displacement amplitude, the frictional force(F_t)-displacement (D) curve, the fretting operating condition diagram and the friction coefficient curve were established. And the wear mechanism of the CF/PEEK composite material was explored through a three-dimensional white light interferometer and a scanning electron microscope (SEM). The results show that with the decrease of the normal load and the increase of the displacement amplitude, the fretting changes from partial slip regime and mixed regime to slip regime. The overall friction coefficient curve is relatively stable. The friction coefficient gradually decreases with the increase of normal load and increases with the rise of displacement amplitude. The wear volume increases with load and displacement amplitude increases. In addition, CF/PEEK composites have better fretting properties, and the main wear mechanisms are abrasive wear and fatigue wear. The analysis of the tribological characteristics of composite materials provides a specific theoretical basis for CF/PEEK composite materials to replace metal implants.