Abstract: In this paper, gangue was purified by a series of process and gangue-supported Fe/FeO_x nanoparticles (nFe/FeO_x-Gangue) were prepared by the liquid-phase reduction method under open atmosphere. The factors including Fe:Gangue mass ratios, B:Fe molar ratios, and the reduction speed were investigated based on a uniform design. XRD, TEM, BET and TG-DTA analysis were used for characterization of synthesized samples. The synthesized nFe/FeO_x-Gangue exists on the surface of gangue or adsorbed on surface, sharp edges and angles of small clay in series with an analogous catenulate formation in rank, indicating that the spherical particles immobilized on clay are clearly separated and well dispersed, displaying small amounts of globular or nubbly aggregates. The comparison results of several samples show that the Fe/ Gangue mass ratio (g/g) should be maintained as 1.6, and the appropriate B/Fe molar ratios are 4 or 4.5. After contacting with nFe/FeO_x-Gangue for 10 min, for Cd(II), the adsorption efficiency on nFe/FeO_x-Gangue is 83% at pH 5.0. The removal efficiency of Cd(II) on nFe/FeO_x-Gangue is largely dependent on pH values. The reusability of nFe/FeO_x-Gangue is evaluated and the results indicate that the reborn nFe/FeO_x-Gangue even could adsorb 99.12% of Cd(II) ions in 5.0 mg/L solution for the sixth successive uses. nFe/FeO_x-Gangue is appropriate to remove Cd(II).