Abstract: Metal-organic framework (MOFs) was an organic-inorganic hybrid material with porous structure formed by self-assembly of metal ions or clusters and organic ligands through coordination bonds. They have the advantages of adjustable frame structure, high porosity, good chemical stability, reproducibility and simple synthesis process. Therefore, it was widely used in adsorption and separation of small molecules, catalytic chemical reaction, catalytic degradation, enrichment of substances, REDOX reaction, drug dilution and other fields. Magnetic metal organic framework (MMOFs) introduces magnetic metal particles on the basis of metal organic framework, greatly improves and optimizes its original performance, enriches the research content of metal organic framework, and widens the application of metal organic framework in food, pesticide and biology analysis. In this paper, the application of magnetic metal-organic framework in bioanalysis was systematically discussed. On this basis, the limitations of current MMOFs materials in this field were summarized, and the new trend of research was proposed.