Abstract: This paper presents a strength criterion and fatigue life prediction method for 2D braided alumina matrix composites under a complex in-plane stress state. The static strength of the material was obtained by in-plane tensile, compression, and pure shear tests. Considering the difference between tensile and compressive properties of materials and the influence mechanism of in-plane tensile and shear coupling on material strength, a revised Hoffman strength theory was proposed. The predicted off-axis tensile strength is consistent with the test results, and the deviation is not more than 10%. Tensile fatigue tests were carried out with the off-axis angle θ=0°, 15°, 30°, 45°, the stress ratio R=0.1, and frequency f=10 Hz. The test results show that the fatigue life decreases with the increase of off-axis angle. Due to the in-plane shear stress component, the fatigue failure is gradually changed from fiber-dominated to fiber-matrix dominated mode. Based on a combination of the uniaxial tensile fatigue life curve, the Broutman-Sahu residual strength model, which is used to characterize the variation of the residual strength with the fatigue cycles, and the modified Hoffman strength theory, the paper proposes a fatigue life prediction model under complex in-plane loading conditions. The fatigue shear damage factor is defined to characterize the effect of the normal and shear stress interaction on fatigue life. The fatigue life prediction model is used to predict the fatigue life of specimens in the off-axis tensile fatigue tests. The predicted result agrees with the test result, and the deviation is within the 1-time life span. The results indicate that the proposed fatigue life prediction model can be used to predict the fatigue life of 2D braided alumina matrix composites under the complex in-plane stress condition with the given stress ratio, temperature, and fatigue load frequency.