胶原蛋白基纳米复合材料的性能及界面研究进展

Progress on properties and interface of collagen-based nanocomposites

  • 摘要: 胶原蛋白(COL)是一种绿色可再生的有机天然高分子材料,具有优异的生物相容性、可生物降解性和低抗原性等特点,将具有独特功能特性的无机纳米材料引入其中,可以开发出兼具二者优异性能的新型COL基纳米复合材料。然而,无机纳米材料与有机COL之间的界面结合特性会显著影响所制备复合材料的性能。因而,有必要研究纳米材料与COL之间的界面结合特性。本文系统回顾了未改性/有机化改性纳米材料对COL基纳米复合材料性能影响的研究现状,重点阐述了通过现代仪器分析表征方法和分子动力学模拟两种方法对纳米材料与COL之间的界面研究进展,对比了两种方法的优缺点,展望了COL基纳米复合材料性能及界面研究未来可能的发展趋势,指出在COL中引入新型纳米材料制备绿色化、多功能化、高性能化、应用多元化的COL基纳米复合材料及利用多种现代仪器分析方法和计算机模拟相结合的手段进行界面研究是未来的主要研究方向。

     

    Abstract: Collagen (COL) is a green and renewable organic natural polymer material with excellent biocompatibility, biodegradability and low antigenicity. A series of novel collagen-based nanocomposites combining excellent properties of two components could be developed by introducing inorganic nanomaterials with unique functional characteristics into collagen matrix. However, the interface interaction characteristics between inorganic nanomaterials and organic COL have a significant effect on the properties of the corresponding nanocomposites. Therefore, it is necessary to investigate the interface interaction between nanomaterials and COL. This paper systematically reviewed the main research status of the effect of unmodified/modified nanomaterials on the properties of COL-based nanocomposite, and summarized the progress of the interface research between nanomaterials and COL through methods of modern instrumental analysis and molecular dynamics simulation. Moreover, the advantages and disadvantages of the two methods were compared. Finally, the possible future research trend of the interface interaction between nanomaterials and COL matrix was prospected. It is pointed out that the introduction of nanomaterials into the COL matrix to prepare environmentally friendly, multi-functional, high-performance, and widely used COL-based nanocomposites, and the combination of modern instrument analysis methods and computer simulation methods to conduct interface research will be the main research directions in the future.

     

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