Abstract: There are critical limitations in numerical simulation of large-thickness composite materials, including lack of real-scale verifications and numerical model to be optimized. In this paper, the process design and model prediction of process parameters were carried out for the large-thickness composite curved cambered component formed by vacuum assisted resin transfer molding through process simulation and experimental verification. Firstly, different process simulation schemes were compared and studied. Then the optimum scheme was used to design the process of the resin infusion, and the experimental verification was carried out. Finally, the process parameter prediction model of different thickness parts was proposed. The results show that the optimal scheme can obtain ideal computational efficiency and flow simulation results simultaneously. The simulation results of the designed process scheme are in good agreement with the experiments. The results obtained by the process parameter prediction model are basically consistent with the simulation results.