Abstract: In order to better isolate or degrade erythromycin, and finally improve the ability to deal with residual erythromycin. Magnetic Fe₃O₄@polyacrylic acid (Fe₃O₄@PAA) erythromycin molecularly imprinted polymer (ERYMIP) and photodegradation TiO₂@polyacrylic acid erythromycin molecularly imprinted polymer (TiO₂@PAA ERYMIP) were prepared, respectively. Scanning electron microscope (SEM), X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysisand (TG) and magnetic hysteresis loop (MHL) were used to characterize the morphology and structure of the imprinted polymers. Experimental results show that Fe₃O₄@PAA ERYMIP has superparamagnetic properties and TiO₂@PAA ERYMIP has photodegradation performance. The maximum adsorption capacity of Fe₃O₄@PAA ERYMIP and TiO₂@PAA ERYMIP are 958.4 mg·g⁻¹ and 1170.2 mg·g⁻¹, respectively. They have good selectivity compared with other antibiotics. Isothermal adsorption studies find that both Fe₃O₄@PAA ERYMIP and TiO₂@PAA ERYMIP are consistent with Langmuir model. The kinetic studies find that the adsorption processes of Fe₃O₄@PAA ERYMIP and TiO₂@PAA ERYMIP conform to the quasi-secondary and quasi-primary models, respectively.