Abstract: Octet-truss is a three-dimensional lattice structure with light configuration and multi-function characteristics. In order to analyze and verify its compression resistance, a method of preparing Octet-truss lattice sandwich panel with continuous fiber was proposed. A set of Octet-truss structure molding tools was designed by this method. Different types of glass fiber and Kevlar fiber specimens were prepared by spatial weaving method and resin curing process, and the axial compression test was carried out. The experimental results show that the mechanical properties of different materials and different sizes of sandwich panels prepared by this method are stable, and the reliability of the preparation process is verified, Combined with the experimental process and electron microscope images, the main failure mode of glass fiber samples is fracture of the struts near the nodes induced by fiber microbuckling, while the Kevlar fiber samples failed by the Euler buckling of the struts.