Abstract: Silk fibroin materials have been made into flexible electronic devices with good biocompatibility, controllable biodegradability and diversity of regeneration morphology. In this paper, the effects of different dissolution methods on the preparation of silk regenerated materials are reviewed. At the same time, the preparation methods and properties of silk fibroin materials such as microspheres, membranes, fibers, gels, scaffolds, etc. are analyzed. Then, the development and application of silk fibroin based flexible electronic materials in recent years are summarized. Although studies have shown that various silk fibroin based advanced materials with excellent properties can be obtained for electronic applications, the industrialization road is still long. Considering the advantages of silk fibroin micro-nano structure and easy regeneration and processing, the flexible electronic products with high sensitivity, biocompatibility, durability and portability are expected to appear.