Abstract: Polyester-polyamide 6 (PET-PA6) bicomponent hollow segmented-pie PET-PA6 microfiber was prepared by spunbond technology, and composited with Lyocell fibers web, and PET-PA6/Lyocell composite nonwoven materials with double-layer composite structure were prepared by high-pressure spunlace. The effects of fiber composite ratio and areal density on the performance of composite nonwoven materials were studied. The results show that the PET-PA6/Lyocell composite nonwoven material has an obvious three-dimensional structure and double-layer composite structure. After spunlacing, the fiber equivalent diameter of PET-PA6 fiber is between 3.60 and 6.50 μm, the diameter of Lyocell fiber is between 9.30 and 11.50 μm, and some fibrillation microfibrils appear. At the same areal density, PET-PA6/Lyocell nonwoven material is compared with PET-PA6 nonwoven material, the hydrophilic property has been significantly improved. When the content ratio of PET-PA6 and Lyocell fiber is 1∶1 (gram weight is 160 g/m²), the air permeability is 249.47 L/(cm²·s), increased by 117.83%; the water vapor permeabi-lity is 4 035 g/(m²·24 h), increased by 36.01%; the softness is 4.39 mm, increased by 67.56%; at the same time, the mechanical properties have been increased, and the aspect ratio of tensile strength is reduced from 1.5 to 1.2, and the phase difference is significantly reduced; but the thermal stability is slightly reduced. As the areal density increasing, the air permeability and water vapor permeability of the composite nonwoven material are gradually decreased, the softness is decreased, and the mechanical properties are increased. The combination of Lyocell fibers have significantly improved the overall performance of nonwoven materials. The three-dimensional and double-layer composite structure of nonwoven fabrics are similar to the microstructure of natural leather, and are expected to be applied in the field of microfiber synthetic leather base.