Abstract: The multiple H-bonds reinforced poly(acrylamide-co-2-vinyl-4,6-diamino-2-vinyl-1,3,5-triazine)/tannic acid (P(Am-co-VDT)/TA) hydrogels were prepared. Through testing and analysis of mechanical properties, micro-morphology and infrared spectrum, it's found that TA cross-linked the hydrogel through hydrogen bonding, making its structure more dense, and the hydrogel has high tensile strength (2.34 MPa) and elongation at break (410%). This is due to the formation of hydrogen-bond “soft” regions between the diaminotriazine (DAT) moieties on the polymer chains and the TA pyrogallol/catechol groups and a “hard” region of H-bonds forming by DAT moieties with itself. Such soft and hard dual-physically crosslinked networks dramatically enhance the mechanical properties of hydrogels in a synergistic manner. Due to the multiple hydrogen bonds, the hydrogel can rapidly response to shape memory within a few minutes. It can be quickly shaped and restored by changing the temperature, and the shape change can be maintained and repeated for many times. In addition, the hydrogels have capacity of physical adsorption of anti-inflammatory drug diclofenac sodium (DS) and other molecules with a specific spatially arranged chemical composition. This research will be of great significance in the fields of biomedicine, tissue engineering and medical materials.