Abstract: Polymethylimide (PMI) foam core sandwich has unique performance advantages, which leads to a wide application in aerospace structures. In order to promote the stabilization, serialization and high performance for PMI foam core sandwich, the present research situation and development trend of PMI foam core sandwich design and manufacturing technology for lifecycle were systematically reviewed. Firstly, the performance and application situation of PMI foam and its core sandwich were summarized, and the market demand of PMI foam core sandwich was analyzed. Then, the key technologies situations of PMI foam core sandwich lifecycle were curtly described, including the research of PMI foam, structure design and analysis, structure curing and forming, repair and maintenance, etc. Finally, the development trend of PMI foam core sandwich was prospected, so that to provide reference for further research.