Abstract: The Ce/MOF-5 materials with different properties were synthesized by means of hydrothermal synthesis method by mixing Ce with the reaction precursors required for the synthesis of metal organic framework materials (MOFs). The synthetic materials were characterized by SEM, XRD and BET, etc. The results show that the Ce/MOF-5 synthesized by different methods shows significant differences in morphology and fluorine adsorption performance. The effect of the initial concentration, pH value and adsorption time on the adsorption effect of F⁻ was also determined. The experiments show that the adsorption of F⁻ by Ce/MOF-5 material synthesized by the "one-pot method" obtains an adsorption balance of 109.6 mg·g⁻¹ at pH=7, with a adsorption time of about 60 min. It conforms to the quasi-second order kinetic model and Freundlich isothermal adsorption model.