Abstract: The tensile residual strength and damage mode of glass fiber/epoxy (GF/EP) composite-aluminum alloy laminates with an open-hole subjected to different thermal exposure temperatures were studied based on experimental and numerical methods, revealing the evolution process of various failure including interlaminar damage, fiber damage and matrix damage. The results show that residual strength of GF/EP composite-aluminum alloy laminates with an open-hole gradually decreases as the thermal exposure temperature increases, followed by a mixed failure mode with fiber fracture and interlaminar delamination. The increasing temperature and open-hole diameter can both lead to a reduction of interlaminar damage area. As the load increases, 0° fiber along the loading direction shows a funnel-shaped damage evolution form, and petal shape for matrix damage. The interlaminar damage presents a pair of symmetrical triangles region with respect to the open-hole. The numerical results show good agreement with test ones based on residual strength and failure mode of GF/EP composite-aluminum alloy laminates.