Abstract: Based on the bionic principle, six sets of bio-inspired flexible protection device were designed and prepared. Two types of composite scales were used. One was made from SiC ceramic and ultra-high molecular weight polyethylene (UHMWPE), the other was made from Al₂O₃ ceramic and UHMWPE. The bio-inspired flexible protection devices were tested. The effects of the types of composite scales, overlapping angle and the bullet impact position on the ballistic performance of the bio-inspired flexible protection device were discussed and analyzed. Results show that the bio-inspired flexible protection device can successfully resist the penetration of bullets (lead core) with a speed of (445±10) m/s, and the signature in the backing material is 5-20 mm. The ballistic performance of the device with SiC-UHMWPE composite scales is significantly better than that of device with Al₂O₃-UHMWPE composite scales. The ballistic performance of the bio-inspired protection device increases with the increasing of overlapping angle. The results of this work can provide theoretical basis and scientific guidance for the research of new type of flexible protection device.