Abstract: Taking the quartz/epoxy composite structure as the object, the global sensitivity theory was adopted to analyze the influences of the input parameters on the strength response of quartz/epoxy composite structure by considering the random characteristics of the input parameters. MATLAB and NASTRAN were combined to obtain the output response after considering all the input parameter randomness, then the adaptive Kriging model was introduced to construct the ultimate surrogate model. On basis of this surrogate model, the reliability of overall strength of the quartz/epoxy composite structure was computed, and the global sensitivity indices reflecting the influences of the input parameters on the output response were also obtained. The importance of the input parameters can be ranked according to the sensitivity results, which can provide guidance information for the design of composite structure.