Abstract: Quasi-static and dynamic nanoindentation techniques were performed to study the surface mechanical properties of hydroxyapatite/polylactic acid (HA/PLA) composites on the nanoscale. The mechanical responses(modulus and hardness) of the composite were obtained by changing the loading and holding time in the static mode. The effects of these experimental parameters on nanoindentation measurement were also discussed. It is found that the loading and unloading time have a significant effect on the experimental results due to creep deformation when the holding time is less than 45 s. It is also found that a "nose" may appear in the unloading segment of the load-displacement curve during nanoindentation when the holding time is short and the unloading time is long. The holding time was set to 45 s in order to avoid the influence of the "nose". The dynamic nanomechanical properties of the material were investigated in the dynamic indentation mode. The results show that the storage modulus and hardness decrease with the increase of the indentation depth. Both nanoindentation and scratch test show that HA improves the mechanical properties of PLA obviously. Comparing with pure PLA, the modulus and hardness of 9wt% HA/PLA composite enhance by 35.5% and 44.7%.The creep depth of 9wt% HA/PLA composites decreases by 9.5%. The maximum depth and residual depth are fewer than that of pure PLA under the same load, showing the greater elastic recovery and resilience of HA/PLA composites.