Abstract: The application of theory of micro-mechanics of failure (MMF) was extended to analyze the fatigue strength for the complex three-dimensional of the continuous fiber reinforced polymer (FRP) composite. The fatigue strength analysis method of the continuous FRP laminate structure was established based on the MMF theory. The strength and mechanical properties of unidirectional laminate of UTS50/E51 were measured by the static loading and fatigue-loading test. The constituent fatigue MMF critical parameters of the UTS50/E51 laminate were characterized and the S-lgN curves of the tensile and compressive fatigue MMF critical parameters of the fiber and matrix were obtained, which provided basis for using the MMF theory to analyze the fatigue strength of the continuous FRP laminates structure. The fatigue tensile strength of the laminates structure of polymer composites was studied based on MMF. The fatigue tension tests for the laminates structure of UTS50/E51 laminate were carried out. The strengths obtained from both theoretical analysis and tests were compared.