Abstract: Due to theosteoinduction of the bone morphogenetic protein-2 (BMP-2) and stabilization of bovine serum albumin (BSA), three types of new biological mat was fabricated, namely silk fibroin (SF)/poly (L-lactide-co-caprolactone)(PLCL) mat loaded with BMP-2 and BSA by coaxial electrospinning (BMP-2-BSA@SF/PLCL, Mat A), SF/PLCL mat loaded with BMP-2 and BSA by blend electrospinning (BMP-2-BSA-SF/PLCL, Mat B), non-loaded SF/PLCL mat (SF/PLCL, Mat C). The results of apparent characteristics show all the fibrous mats present homogeneous network structure, and the core-shell structure is formed only in Mat A. The physicochemical properties results show contact angle and mechanical properties of Mat A, Mat B and Mat C increase in turn. Although each group has good biocompatibility and barrier function, Mat A which has the ability of sustained drugrelease can stimulate growth and osteogenic differentiation of cells more effectively. The BMP-2-BSA@SF/PLCL fibrous mat can meet the requirements of guided bone regeneration (GBR) and will be used as the ideal carrier for bone defect repair.