Abstract: Failure modes and its influence factors under external load of CFRP lattice sandwich structure containing hole were investigated by experiment and finite element method. Failure modes were revealed firstly by experiment. Then a progressive damage failure model was established. Based on this model, influences of hole shape, opening rate and hole position on bending strength of CFRP lattice sandwich structure were discussed. The results show that when the panel is thicker, the main failure modes of the lattice sandwich structure containing hole are panel wrinkling and node debonding. The numerical result matches the experiment well with the error of the ultimate load of 9.1%. When the opening rate φ is less than 1.3%, the bending bearing capacity of CFRP lattice sandwich structure is uncorrelated with hole shape. When φ is from 1.3% to 8.5%, the bending bearing capacity of sandwich structure containing a rounded hole is larger. In other cases, the bending bearing capacity of sandwich structure containing a quadrate hole is larger. The holes located at the geometric center or near edges of the CFRP lattice sandwich structure have greater influence on the bending bearing capacity.