Abstract: Heavy press frame made by prestressed carbon fiber winding was studied Carbon fiber(T700SC-12000) and titanium alloy(TC11) frame were selected as prestressed parts, New materials were applied to main parts of 25 MN die forging press and carbon fiber winding frame structure was designed. Press frame model was established according to the input parameters. Meantime, A variable tension winding was designed for the 25 MN die forging press and the results using the finite element were analyzed. The analysis results show that prestressed carbon fiber winding technology greatly improves the pre-tightening force of the protection of the beam and column of heavy press, and increases the reliability of the parts, reduces the manufacturing risk of large parts. The strength of heavy press frame made by prestressed carbon fiber winding meet the requirements, the Von Mises of the prestressed frame is 863.9 MPa and less than the yield strength of TC11. The mass loss effect is obvious, mass of press frame is decreased from 8 022 kg to 1 950.76 kg, decreased by 75.7%.