Abstract: Based on the theory of bionics, nano β-tricalcium phosphate-collagen/chondroitin sulfate (nano β-TCP-Col/CS) scaffold composites were modified by dehydrathermal (DHT) and 1-Ethyl-3-(3-Dimethylaminopropyl) (EDC) using nano β-tricalcium phosphate(nano β-TCP), collagen(Col) and chondroitin sulfate(CS) as the raw materials. The structure and properties of nano β-TCP-Col/CS scaffold composites were investigated by XRD, AFM, SEM, XPS, TG and degradation and mineralization in simulated body fluid (SBF). The results indicate that the size of β-TCP is 41.3nm. Due to a strong interaction among nano β-TCP, Col and CS, nano β-TCP-Col/CS scaffold composites has strong stability, mineralized biological activity and appropriate biodegradability, which is a kind of potential dental restorative materials.