Abstract: In order to improve the precision of inhomogeneous material interface crack tip fracture parameters which based on the inhomogeneous material interface fracture mechanics, Cell-Based smoothed finite element method(Cell-SFEM) and inhomogeneous material interaction integral, the Cell-Based smoothed finite element method was put forward to work out the inhomogeneous materials interface crack tip fracture parameters, and the interaction integral of inhomogeneous material based on Cell-Based smoothed finite element method was deduced. The normalized stress intensity factor in inhomogeneous material interface crack tip was solved. Compared with the reference solution, the relationship between the sizes of interaction integral region, the number of smoothing element and normalized stress intensity factor was discussed. The results of numerical example show that this method has high computational accuracy. It is not sensitive to integral area size as its features, and it can provide the basis for design and manufacture anti-failure of inhomogeneous material.