Abstract: Generalized differential quadrature (GDQ) method was used to analyze and optimize the vibration and buckling of composite laminate under different boundary conditions and linearly varying in-plane loads. Since GDQ method led to calculation oscillation and non-convergence for the case of buckling for composite laminate under linearly varying in-plane loads, load perturbation strategy was developed to achieve the stable and efficient computation of buckling for composite laminate by GDQ method. Influence of ply angle on the comprehensive performance of composite laminate was analyzed base on the normalized index of fundamental circle frequency and critical buckling load coefficient, while the stacking sequence of composite laminate was optimized by using the direction search simulated annealing algorithm. The results show that ply angle variation has greater effect on buckling performance than frequency. Boundary condition is the least one to affect the optimal comprehensive performance of composite laminate under the bending load in the family of linearly varying in-plane loads, on the contrary, the most dominant factor to affect the optimal ply angle. The study provides a reference for the design of composite laminate under complex loading.