Abstract: Extracted active ingredients(SBGE)from natural plant Scutellaria baicalensis Georgi (SBG) and compounded with biodegradable material poly (butylene succinate) (PBS). In order to improve the compatibility between them, two PBS modified products were synthesized: PBS—OH and PBS—COOH. The interfacial interactions of the SBGE/PBS composites were discussed, and the effects of SBGE on the performances of PBS materials were studied. The results show that the introduction of the —OH and —COOH improve the compatibility between the matrix and hydrophilic extracts which reinforce the hydrogen bonds between each other and enhance the interfacial bond strength. The addition of SBGE has almost no impact on the crystalline of PBS. Thermal properties of 1% SBGE/PBS, 3% SBGE/PBS—OH and 1% SBGE/PBS—COOH are the best, and higher than the matrix itself; mechanical properties of 7% SBGE/PBS, 3% SBGE/PBS—OH and 1% SBGE/PBS—COOH are better than others; and the change of antibacterial properties all further indicate the existences of the interaction. The comprehensive properties of the SBGE/PBS—OH and SBGE/PBS—COOH are superior to SBGE/PBS.