Preparation and application of sodium alginate hydrogel film loaded with nano-silver/graphene composite

WANG Tingting; WANG Jinqing; YUE Mingqiang; FAN Zengjie; YANG Shengrong

doi:10.13801/j.cnki.fhclxb.20201214.002

Volume 38 Issue 9

Sep. 2021

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Article Navigation > Acta Materiae Compositae Sinica > 2021 > 38(9): 3016-3025

WANG Tingting, WANG Jinqing, YUE Mingqiang, et al. Preparation and application of sodium alginate hydrogel film loaded with nano-silver/graphene composite[J]. Acta Materiae Compositae Sinica, 2021, 38(9): 3016-3025. doi: 10.13801/j.cnki.fhclxb.20201214.002

Citation:

WANG Tingting, WANG Jinqing, YUE Mingqiang, et al. Preparation and application of sodium alginate hydrogel film loaded with nano-silver/graphene composite[J]. Acta Materiae Compositae Sinica, 2021, 38(9): 3016-3025. doi: 10.13801/j.cnki.fhclxb.20201214.002

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Preparation and application of sodium alginate hydrogel film loaded with nano-silver/graphene composite

doi: 10.13801/j.cnki.fhclxb.20201214.002

WANG Tingting^{1, 2, 3
,},
WANG Jinqing^{1, 2
,},
YUE Mingqiang^3
,,
FAN Zengjie^4
,,
YANG Shengrong^{1, 2
,
,}

1.
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
2.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
3.
School of Chemical Engineering, Northwest Minzu University, Lanzhou 730000, China
4.
School of Stomatology, Lanzhou University, Lanzhou 730000, China

Received Date: 2020-10-14
Accepted Date: 2020-12-03

Available Online: 2020-12-14

Publish Date: 2021-09-01

Abstract

Abstract

Sodium alginate (SA) is a natural polymer material that has been widely studied and used in the biomedical field. Nano-silver (Ag) has been proven to present good antibacterial properties, but its application is limited due to its easy agglomeration. In this paper, a series of Ag-graphene composites (Ag-GO) were prepared and characterized by loading Ag nanoparticles on the surface of graphene oxide (GO) sheets. Ag-GO was then added into SA, and a double-layered SA hydrogel film (Ag-GO/SA) carrying Ag-GO was prepared by sol-gel process. FTIR, XRD and SEM characterizations were used to determine the chemical structure and micromorphology of Ag-GO/SA. In addition, swelling ability, mechanical and antibacterial properties, as well as in-vitro cytotoxicity and in-vivo wound healing ability of Ag-GO/SA samples were also evaluated. The results show that the prepared Ag-GO/SA has good swelling property, sufficient mechanical strength, excellent wound healing and antibacterial properties. Specially, the optimum hydrogel of Ag-GO/SA can promote wound healing in SD rats, with a wound healing rate of up to 98%, presenting great application potential as a new type of wound dressing.
- nano-silver/graphene composite,
- sodium alginate,
- double-layer hydrogel,
- antibacterial property,
- wound healing
Long Abstrsct
Innovation Points

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References(25)

References

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