聚吡咯/壳聚糖-海藻酸钠复合微球的制备及其药物缓释性能

李莎; 张新浩; 贾睿; 罗钰; 邢建宇

聚吡咯/壳聚糖-海藻酸钠复合微球的制备及其药物缓释性能

李莎^{1, 2, 3},
张新浩^{1, 2, 3},
贾睿^{1, 2, 3},
罗钰^{1, 2, 3},
邢建宇^{1, 2, 3, ,}

1.
长安大学　水利与环境学院, 西安 710054
2.
长安大学　旱区地下水文与生态效应教育部重点实验室西安 710054
3.
长安大学　水利部旱区生态水文与水安全重点实验室西安 710054

基金项目: 陕西省教育厅科学研究计划项目资助(22JE003); 陕西省自然科学基础研究计划资助项目(No. 2020JM-226)

详细信息

通讯作者:
邢建宇(1979—)，男，博士，副教授，主要从事环境友好材料的制备及应用。　E-mail: xingjy@chd.edu.cn

中图分类号: TB332
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- 被引次数: 0
出版历程
- 收稿日期: 2023-09-12
- 录用日期: 2023-11-24
- 网络出版日期: 2023-11-27
- 刊出日期: 2024-07-15

Preparation of polypyrrole/chitosan-sodium alginate composite microspheres and their slow-release properties

LI Sha^{1, 2, 3},
ZHANG Xinhao^{1, 2, 3},
JIA Rui^{1, 2, 3},
LUO Yu^{1, 2, 3},
XING Jianyu^{1, 2, 3
, ,}

1.
School of Water and Environment, Chang’an University, Xi’an 710054, China
2.
Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of the Ministry of Education, Chang’an University, Xi’an 710054, China
3.
Key Laboratory of Eco-hydrology and Water Security in Arid and Semi-arid Regions of Ministry of Water Resources, Chang’an University, Xi’an 710054, China

Funds: Scientific Research Project supported by Shaanxi Provincial Education Department (22JE0030); Supported by Natural Science Basic Research Program of Shaanxi Province (No.2020JM-226)

摘要

摘要: 开发新型药物控释复合材料在医药、农业等领域具有重要意义。以壳聚糖和海藻酸钠(CS-Alg)凝胶网络为载体，使用原位氧化法将聚吡咯(PPy)引入其中，制备出PPy/CS-Alg复合缓释材料。通过SEM、FT-IR、XPS、UV-vis-NIR对其微观结构、结构组成、光热转换性能进行了研究，并以吲哚丁酸(IBA)为模型药物分子，研究了其缓释性能。结果表明，PPy/CS-Alg微球的多孔微观形貌有利于IBA的装载和释放，原位氧化形成的氧化态PPy在CS-Alg凝胶网络可缓慢还原，并从带正电状态变为不带电状态，该种带电状态的改变，可促使IBA从PPy/CS-Alg微球的凝胶网络中缓慢释放，长效释放率可达到56.12%。另外基于PPy的光热效应，模拟太阳光照射下PPy/CS-Alg微球的温度可从26 ℃最高上升到39 ℃，这有利于在微球内部到外部形成温度梯度，进一步增强IBA的缓释能力。以PPy的缓慢还原和光热效应开发的植物生长素IBA控释材料在农业领域具有广阔的应用前景。
- 复合凝胶微球 /
- 聚吡咯 /
- 吲哚丁酸 /
- 光热效应 /
- 药物释放
Abstract: The development of novel drug controlled release composite materials is of great significance in the fields of medicine and agriculture. Using chitosan and sodium alginate (CS-Alg) gel network as carrier, PPy/CS-Alg composite slow-release material was prepared by in-situ oxidation of polypyrrole (PPy). The microstructure, structure composition and photothermal conversion properties were studied by SEM, FT-IR, XPS and UV-vis-NIR. Indolebutyric acid (IBA) was used as a model drug molecule to study its sustained release performance. The results show that the porous morphology of PPy/CS-Alg microspheres is conducive to the loading and release of IBA. The PPy oxidized state formed by in-situ oxidation can be slowly reduced in the CS-Alg gel network, and changes from a positive state to an uncharged state. As a result, IBA can be slowly released from the gel network of PPy/CS-Alg microspheres, with the long-term release rate of 56.12%. In addition, the temperature of PPy/CS-Alg microspheres under simulated sunlight can rise from 26℃ to 37℃ based on the photothermal effect of PPy, which is conducive to the formation of temperature gradients inside and outside the microspheres and further enhancing the slow-release of IBA. The controlled release material of auxin IBA based on the slow reduction and photothermal effect of PPy has broad application prospects in the agricultural field.
- composite gel microspheres /
- polypyrrole /
- indolebutyric acid /
- photothermal effect /
- drug release

HTML全文

图 1 CS-Alg(a, b, c)和PPy/CS-Alg(d, e, f)微球的样品外貌及SEM图

Figure 1. Photograph and SEM of CS-Alg (a, b, c) and PPy/CS-Alg (d,e,f) microspheres

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图 2 CS-Alg和PPy/CS-Alg微球的红外光谱图

Figure 2. FTIR spectra of CS-Alg and PPy/CS-Alg microspheres

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图 3 CS-Alg和PPy/CS-Alg微球的紫外-可见漫反射吸收光谱图

Figure 3. UV-VIS diffuse reflection absorption spectra of CS-Alg and PPy/CS-Alg microspheres

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图 4 CS-Alg和PPy/CS-Alg复合微球不同时刻下的红外热成像图

Figure 4. Infrared thermal imaging of CS-Alg and PPy/CS-Alg composite microspheres at different times

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图 5 不同含量PPy对IBA释放的影响

Figure 5. Effects of different content of PPy on IBA release

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图 6 PPy/CS-Alg在不同浓度亚硫酸钠溶液中的IBA释放百分比

Figure 6. IBA release percentage of PPy/CS-Alg in different concentrations of Na₂SO₃ solutions

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图 7 光照条件下CS-Alg和PPy/CS-Alg复合微球IBA释放比较

Figure 7. IBA release comparation of CS-Alg and PPy/CS-Alg microspheres under light

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图 8 PPy/CS-Alg释放前后C1 s(a)、N1 s(b)、O1 s(c)的XPS分析

Figure 8. C1 s(a)、N1 s(b)、O1 s(c) XPS spectra of PPy/CS-Alg before and after release

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图 9 释放前后PPy/CS-Alg微球的Zeta电位图

Figure 9. Zeta potential diagram of PPy/CS-Alg microspheres before and after release

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图 10 释放前后PPy/CS-Alg微球的红外光谱

Figure 10. FTIR spectra of PPy/CS-Alg microspheres before and after release

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