载药纺织品制备方法的研究进展

李长静; 赵立环; 王玉稳; 李艳艳; 杨玉洁; 闫子妍; 陈雨龙

doi:10.13801/j.cnki.fhclxb.20230802.001

载药纺织品制备方法的研究进展

doi: 10.13801/j.cnki.fhclxb.20230802.001

1.
天津工业大学　纺织科学与工程学院，天津 300387
2.
天津齐邦新材料有限公司，天津 300380

基金项目: 天津市科技计划项目(22YDTPJC00820)；中国纺织工业联合会科技指导性计划项目(2021065)

详细信息

通讯作者:
赵立环，博士，副教授，硕士生导师，研究方向为生物医用纺织品的制备、理论及应用　E-mail: zhaolihuan@tiangong.edu.cn

中图分类号: TS195.5；TB332
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- 文章访问数: 484
- HTML全文浏览量: 286
- PDF下载量: 30
- 被引次数: 0
出版历程
- 收稿日期: 2023-05-08
- 修回日期: 2023-07-02
- 录用日期: 2023-07-23
- 网络出版日期: 2023-08-02
- 刊出日期: 2024-01-01

Research progress of drug-loaded textiles in the preparation methods

1.
School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
2.
Chybond Materials CO., LTD., Tianjin 300380, China

Funds: Science and Technology Plan Project of Tianjin (22YDTPJC00820); Science and Technology Guidance Project of China National Textile and Apparel Association (2021065)

摘要

摘要: 纺织品具有比表面积大、柔韧性好、适用性广、对药物具有良好的负载及缓释控释能力等优点，被广泛用于药物负载。载药纺织品的制备方法主要包括纺丝法、后整理法及复合法，以其制备方法为切入点对载药纺织品进行分类，然后阐述了各类载药纺织品制备方法、释药特征、适用性及其研究现状，并归纳了各类载药纺织品的制备方法的特征和优缺点，最后提出了载药纺织品的未来研究方向，为进一步研究载药纺织品及其制备方法提供参考。
- 载药纺织品 /
- 药物载体 /
- 纺丝法 /
- 后整理法 /
- 纳米纤维
Abstract: Textiles are widely used for drug loading because of their large specific surface area, good flexibility, wide applicability, good loading of drugs and slow release and controlled release ability. The preparation methods of drug-loaded textiles mainly include spinning method, finishing method and composite method. The preparation methods of drug-loaded textiles were used as the starting point to classify the drug-loaded textiles, the preparation methods, drug release characteristics, applicability and current research status of each type of drug-loaded textiles were described, the preparation characteristics, advantages and disadvantages of preparation methods of each type of drug-loaded textiles were summarized, and finally the future research directions of drug-loaded textiles were proposed, to provide reference for further research on drug-loaded textiles and their preparation methods.
- drug-loaded textiles /
- drug carriers /
- spinning method /
- finishing method /
- nanofibers

HTML全文

图 1 羧甲基白芨多糖-聚乙烯醇(CBSP-PVA)湿纺纤维负载聚多巴胺@二甲双胍(PDA@Metformin)的制备流程 ^[42]

Figure 1. Preparation process of carboxymethylated bletillastriata polysaccharide-polyvinyl alcohol (CBSP-PVA) wet-spun fibers loaded with polydopamine@metformin (PDA@Metformin)^[42]

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图 2 PVA/聚丙烯酸(PAA)-表没食子儿茶素没食子酸酯(EGCG) pH响应纤维的制备流程与释放效果图^[46]

Figure 2. pH-responsive fibers of PVA/polyacrylic acid (PAA)-epigallocatechin gallate (EGCG) preparation process and release effect diagram^[46]

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图 3 用于治疗多药耐药癌细胞的阿霉素(DOX)@层状双氢氧化物(LDH)/α-生育酚琥珀酸酯(α-TOS)/聚乳酸-羟基乙酸共聚物(PLGA)短纳米纤维的制备(a)和药物释放(b)示意图^[47]

Figure 3. Schematic illustration of the preparation (a) and drug release (b) of doxorubicin (DOX)@layered double hydroxide (LDH)/α-tocopherylsuccinate (α-TOS)/poly(lactic-co-glycolic acid) (PLGA) short nanofibers for the treatment of multidrug resistance cancer cells^[47]

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图 4 多功能敷料的制作(a)及伤口愈合过程示意图((b), (c))^[50]

Figure 4. Schematic illustration of the fabrication (a) of the multi-functional dressing and the wound healing process ((b), (c))^[50]

NPs—Nanoparticles; BMSCs—Bone marrow mesenchymal stem cells; PCL—Polycaprolactone

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图 5 茶碱/聚乳酸(PLA)纳米纤维的制备与释放流程图^[52]

Figure 5. Flow chart of preparation and release of the ophylline/polylactic acid (PLA) nanofibers^[52]

PBS—Phosphate buffered solution

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图 6 天然多糖微胶囊与棉织物结合原理图^[55]

Figure 6. Principle diagram of natural polysaccharide microcapsules combined with cotton fabric^[55]

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图 7 没食子酸功能化聚赖氨酸(GA-PL)接枝的棉纤维的制备示意图^[59]

Figure 7. Schematic illustration of the preparation of cotton fiber grafted with gallic acid functionalized polylysine (GA-PL)^[59]

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图 8 共混纤维素-壳聚糖气凝胶微纤维(CHCLAFs)的特点^[61]

Figure 8. Characteristics of co-mingled chitosan-cellulose aerogel microfibers (CHCLAFs) ^[61]

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图 9 聚乙二醇(PEG)-壳聚糖(CS)功能性涂层的制备流程^[63]

Figure 9. Preparation process of the polyethylene glycol (PEG)-chitosan (CS) coating^[63]

STS—Sodium tanshinone IIA sulfonate

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图 10 聚己内酯(PCL)纳米纤维上的自组装肽(SAPs)逐层涂层示意图^[65]

Figure 10. Schematic illustration of the layer-by-layer coating of self-assembling peptide (SAPs) on polycaprolactone (PCL) nanofibers^[65]

pDNA/PEIpro—Plasmid DNA/polyethylenimine pro

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图 11 DOX-PLGA-聚乙烯亚胺(PEI)-二乙烯三胺-五乙酸二酐(DTPA)-Gd/透明质酸(HA) (PGH)微球的制备^[68]

Figure 11. Preparation of DOX-PLGA-polyethylenimine (PEI)-diethylenetriamine-pentaacetic dianhy-dride (DTPA)-Gd/hyaluronic acid (HA) (PGH) microspheres^[68]

SFs—Short fibers; HV—High voltage

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图 12 热致变色水凝胶功能化纺织品的制备工艺及释药原理(右上角是链式光子晶体结构的SEM图像)^[69]

Figure 12. Preparation process of thermochromic hydrogel-functionalized textiles and the principle of drug release (Upper right corner is the SEM image of the chain photonic crystal structure)^[69]

P(NIPAM-AAc)—Poly(N-isopropylacrylamide-co-acrylic acid); β-CD-Mox—β-cyclodextrin-moxifloxacin

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表 1 载药纺织品的制备方法及其优缺点

Table 1. Preparation methods for drug-carrying textiles and their advantages and disadvantages

Preparation of drug-loaded textiles			Preparation characteristics	Advantages	Disadvantages	Ref.
Spinning method	Wet spinning		Preparation of a spinning solution spiked with a drug, which forms a fine stream through the spinneret and forms primary fibres in the coagulation bath	Faster spinning speed, easy to achieve industrial production	Less variety of polymer materials, limited choice; Large amount of solvent use and easy to have residue	[39]
	Electrostatic spinning	Co-blended electrospinning	Electrostatic spinning of drug and polymer blends	Simple spinning device, low cost, controllable process	Presence of pre-emergent drug release problems	[43]
		Coaxial electrospinning	Simultaneous spinning of two spinning liquids into core-shell structured fibres through separate syringes	Two separate drug solvents can be prepared to achieve controlled and sustained release of drugs	Spinning is complex and difficult, spinning process is not easy to control	[1, 71]
		Emulsion electrospinning	Hydrophilic and hydrophobic polymers are electrospun by adding an emulsifier to obtain a spinning solution	Adjustment of emulsion parameters can control the release curve, good slow release effect, simple preparation	Requires the addition of surfactants, which may be toxic to biological systems	[71-73]
		Layer-by-layer electrospinning	Continuous electrostatic spinning of multilayer nanofibre films	It can load with a variety of drugs and controll release based on layer thickness	Slow production speed and high cost	[44]
Finishing method	Impregnation	Impregnation method	Soak the fabric in the finishing agent, dehydrate and bake	Simple operation, low cost, less impact on fabric moisture permeability and breathability	Poor washing fastness of the finishing fabric and high consumption of finishing solution	[54, 74]
		Dipping and rolling method	Soak-roll-dry finishing of the drug onto the fabric	Fastness of the fabric to washing is improved, and the amount of finishing agent is relatively saved	Mechanical strength and moisture permeability of the fabric has decreased	[57, 75]
		Chemical grafting method	Drug loading onto the fabric by chemical bonding	Easy to count the drug load, drug and fabric bonding stability and fastness	High requirements for reactive functional groups and changes in chemical structure easily lead to changes in functional conformation	[74, 76]
		Supercritical CO₂ fluid delivery technology	Dissolving or dispersing drug loading into polymeric matrices using supercritical fluids	It can maintain the stability of the drug	Changes in fiber properties can occur	[77]
	Coating	Coating method	Apply the drug solution evenly to the surface of the fabric	Simple preparation method, high drug loading and release	Fabric has a poor feel and taking properties	[78]
	Coating	Layer-by-layer self-assembly technology	Deposition of alternating layers of drug-carrying film by intermolecular interactions	Multiple and bulk drug loading and controlled drug release are possible	Technique is time consuming and the repeated deposition of layers can lead to cross contamination	[79]

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