Abstract: In order to prevent the conglomerating of nano hydroxyapatite (nano HAP) powders, the nano HAP/polyamide 6 (PA6) composite powders were prepared by solvent precipitation method, and nano HAP/PA6 composites were obtained through hot-press forming of the powders. Then, the constituent, structure and morphology of nano HAP/PA6 composites were investigated using FTIR, XRD and SEM, and thermal stability, mechanical properties and cellular compatibility of composites were measured as well. The results show that the crystalline size of prepared nano HAP/PA6 composites is uniform, and PA6 only has the crystal of α form. For new hydrogen bonds and COO—Ca forming on the interface of nano HAP and PA6, the composites have good synthetic performances. Nano HAP/PA6 composite does not split within 350 ℃, and the mechanical properties are close to human skeleton. The bending strength, compressive strength and elastic modulus of 50wt% nano HAP/PA6 composite are 146.87 MPa, 98.44 MPa and 5.44 GPa, respectively. The situations of MG-63 bone tumor cells attaching and growth on the surfaces of nano HAP/PA6 composites are good, which indicates the nano HAP/PA6 composites have good cellular compatibility. The conclusions obtainted show that nano HAP/PA6 composites have application values in bone repair aspect.