生物活性玻璃/聚乳酸组织工程支架在 SBF溶液中的降解和矿化性能

葛建华; 王迎军; 陈晓峰

生物活性玻璃/聚乳酸组织工程支架在 SBF溶液中的降解和矿化性能

1.
山东大学材料科学与工程学院, 济南 250061;
2.
华南理工大学材料科学与工程学院, 广州 510640;
3.
山东大学材料液固结构演变与加工教育部重点实验室, 济南 250061

基金项目: 国家自然科学基金(51072055); 国家自然科学基金重点项目(50830101); 国家重点基础研究发展计划(973计划)(2011CB606204)

详细信息

通讯作者:
葛建华, 博士, 讲师, 主要从事材料学研究 E-mail: gjh100000@sohu.com

中图分类号: TB332
计量
- 文章访问数: 1579
- PDF下载量: 851
- 被引次数: 0
出版历程
- 收稿日期: 2010-09-13
- 修回日期: 2011-03-15
- 刊出日期: 2011-10-15

Degradable performance and bio-mineralization function of bioglass/poly tissue engineering scaffold in SBF

1.
School of Materials Science and Engineering, Shandong University, Jinan 250061, China;
2.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China;
3.
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China

摘要

摘要: 利用扫描电镜、X衍射仪以及红外漫反射仪, 并通过对生物活性玻璃/聚乳酸组织工程支架在模拟体液(SBF)中失重率及模拟体液pH值的变化的检测, 系统研究了生物活性玻璃/聚乳酸组织工程支架在SBF中的降解和矿化性能。结果发现: 随着含有生物活性玻璃的聚乳酸支架在SBF溶液中浸泡时间的增长, SBF的pH值不断下降; 含有生物活性玻璃的聚乳酸支架的质量不断下降。XRD、FTIR谱图和SEM图像表明: 在SBF中浸泡一定时间后, 有无定型的或结晶不完善的磷灰石在含有生物活性玻璃的聚乳酸支架的表面沉积形成。
- 生物活性玻璃 /
- 聚乳酸 /
- 组织工程支架 /
- 降解 /
- 矿化
Abstract: The degradable performance and bio-mineralization function of bioglass/poly(lactic acid) tissue engineering scaffolds were systematically studied in the simulated body fluid (SBF) by measuring pH value of SBF, the loss mass rate of the scaffolds and analyzing SEM pictures, XRD and FTIR spectra of scaffolds' surface. It was found that in SBF, the pH value of SBF with bioglass/poly(lactic acid) tissue engineering scaffolds and the mass of bioglass/poly(lactic acid) scaffolds decreases with the prolongation of time. SEM pictures and XRD, FTIR spectra showed that there appears the deposition of carbonate hydroxyl apatite on the surface of the bioglass/poly(lactic acid) tissue engineering scaffolds. The result shows that the bioglass/poly(lactic acid) tissue engineering scaffolds have good bio-mineralization function.
- bioglass /
- poly(lactic acid) /
- tissue engineering scaffold /
- degradation /
- bio-mineralization