Abstract: Contact angle between epoxy and different kinds of carbon fibers was investigated first. Work of adhesion at different temperatures was studied by means of Young-Dupre method and Wu method. The influence of resin curing on wetting and adhesive interaction of fibers and resin was then analyzed. The results show that the wetability between T300, CCF, T700 fibers and AG80 resin is improved by increasing the temperature. Comparing with the sized fibers, polar component of surface energy of the desized fibers is lower, and wetting and adhesive interaction with epoxy AG80 resin is worse. Before the chemical reaction of epoxy system starts, wetting between AG80/DDS system and T700 fiber is better than AG80 pure resin and T700 fiber, but work of adhesion is lower. And wetting and adhesive interaction between AG80/DDS, E51/DDS system and T700 fiber are improved as curing time expands at 110 ℃.