Preparation and characterization of nano-hydroxyapatite/ chitosan-chondroitin sulfate composite materials

Nano-hydroxyapatite/chitosan-chondroitin sulfate composites with different mass ratios were prepared through the co-precipitation method. The properties of these composites were characterized and analyzed by means of XRD, SEM, TGA and Universal Testing Machine. The change of the mineralization surface of the composite, pH and the concentration of system in the simulated body fluid were observed. The results show that the nano-hydroxyapatite/chitosan-chondroitin sulfate composites have small influence on the body microenvironment, a good mineralization effect on the surfaces and an excellent biocompatibility and osteoconduction property. The maximum compressive strength value is 42.3MPa at 50% HA. The n-HA/CS-ChS composite can meet the demand of reparation and substitution of osteo-tissue engineering and will be the load-bearing substitute to treat bone defects.