Syntheses and cell compatibilities of CPP/CS composite for bone repair

A series of macroporous calcium polyphosphate/chitosan(CPP/CS) composite rod and microporous CPP/CS composite particle were synthesized with CPP and CS using two technologies by a heat-dispersion suspension complex method. The structure and morphology of the composites were measured by IR spectrum and SEM. The hydrogen bond was formed between —NH₂ of CS and —P O of CPP in the composites. The aperture of the macroporous composite is about 50~300μm, the porocity is 71.13%, which was determined by the ethanol infiltration method. And for the microporous composites, the aperture and porocity are 10~100μm and 40.76%, respectively. The former is suitable for the need of bone tissue engineering scaffold material, but the later is not suitable. The cell compatibility of macroporous composite was better than that of microporous composite. The cell compatibility is the best when CPP/CS=7/3. The compression strength of CPP is increased by the complex method. And the compression strength of composite is also the highest when CPP/CS=7/3.