Preparation of hydroxyapaite/2, 3-dialdehyde bacterial cellulose composite via biomimetic route

Bacterial cellulose (BC) is a kind of biomedical scaffold with nano network. BC should be oxidized to 2, 3-dialdehyde bacterial cellulose (DABC) by sodium periodate to make BC degradable. By the biomimetic route，the degradable HA/DABC composites for bone tissue engineering were prepared. It was observed that the apatite mineralized on DABC via the biomimetic route together with degradation of DABC by SEM. The HA/DABC composites acquired were proved by SEM，EDS and XRD. There was apatite formation on the surface and inside of the DABC via 7 days biomimetic mineralization. The ratio of calcium phosphate to the apatite is 1.75 by EDS.  It was proved to be hydroxyapatite mainly with a little carbonate hydroxyapatite by XRD. It is shown that the degradable HA/DABC composites for bone tissue engineering could be prepared via the biomimetic route.