Properties of embolic microcapsules loading capecitabine

The Ca-Alg (Sodium Alginate) beads with smooth surface, good sphericity and dispersivity, and average size of 210 μm were prepared by the electronic droplet generator, and Alg and chitosan (Chi) were used as wall materials. Then embolic Ca-Alg/Chi microcapsules loading CAP (Capecitabine) were prepared by one-step method and two-step method. Effect of CAP concentrations on drug-loading and drug-release of the microcapsules were investigated. The results show that the drug-loading increases with the CAP concentrations, but the encapsulation efficiency decreases. The cumulative amount of CAP released from the microcapsules is lower than 20% in 0.5 h, which indicate that there is no initial burst release. The embolic microcapsules are likely to be a new dosage form of embolic anti-tumor drugs.