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不同取代羧甲基壳聚糖的制备及其对医用透析纸性能的影响

付柄清 左金华 章飞洋 熊方涛 杨俊 赵会芳 沙力争 陈建斌

付柄清, 左金华, 章飞洋, 等. 不同取代羧甲基壳聚糖的制备及其对医用透析纸性能的影响[J]. 复合材料学报, 2024, 42(0): 1-10.
引用本文: 付柄清, 左金华, 章飞洋, 等. 不同取代羧甲基壳聚糖的制备及其对医用透析纸性能的影响[J]. 复合材料学报, 2024, 42(0): 1-10.
FU Bingqing, ZUO Jinhua, ZHANG Feiyang, et al. Preparation of carbonxymethyl chitosan and its effects on medical dialysis paper[J]. Acta Materiae Compositae Sinica.
Citation: FU Bingqing, ZUO Jinhua, ZHANG Feiyang, et al. Preparation of carbonxymethyl chitosan and its effects on medical dialysis paper[J]. Acta Materiae Compositae Sinica.

不同取代羧甲基壳聚糖的制备及其对医用透析纸性能的影响

基金项目: 浙江省“尖兵”“领雁”科技计划项目(2023 C01195)
详细信息
    通讯作者:

    沙力争,博士,教授,硕士生导师,研究方向为特种纸基功能材料及清洁化生产技术等。 E-mail: slz9966@163.com

  • 中图分类号:  TS761.2; TB332

Preparation of carbonxymethyl chitosan and its effects on medical dialysis paper

Funds: The “Pioneer” and “Leading Goose” R&D Program of Zhejiang (No. 2023 C01195)
  • 摘要: 为了改善壳聚糖的水溶性,拓展其在造纸领域的应用,本研究以壳聚糖(CS)为主要原料,采用氯乙酸作为醚化剂,在碱性条件下进行羧甲基化反应,通过控制反应温度、时间和pH值来得到不同取代位点的羧甲基壳聚糖(CMCS),利用红外光谱和核磁氢谱对CMCS产物进行结构表征和分析,并测定了其取代度及在水中的溶解度;最后将制备好的CMCS作为添加剂用于透析纸的制备,研究其用量对透析纸物理强度、透气度及抗菌性能的影响。结果表明:添加不同取代位点的羧甲基壳聚糖对透析纸的强度均有所改善,相对于氨基位取代的CMCS(N-CMCS)和氨基及羟基位同时取代的CMCS(N,O-CMCS),添加羟基位取代的CMCS(O-CMCS)对透析纸的增强效果最为显著。当O-CMCS添加量为2.5% 时,纸张的干、湿抗张强度、耐破指数分别为61.6 N·m·g−1、8.61 N·m·g−1和6.19 kPa·m2·g−1,比未添加时分别提高了18.8%、113%和91.0%;纸张的透气度为7.98 µm·(Pa·s) −1,满足透析纸的高透气性要求。此外,添加O-CMCS、N-CMCS 和 N,O-CMCS的纸张均具有较好的抗菌性,对大肠杆菌的抑菌率分别达到86.7%、83.8%和83.6%。

     

  • 图  1  壳聚糖(CS)和氨基位取代的羧甲基壳聚糖(N-CMCS)、羟基位取代的CMCS(O-CMCS)、氨基及羟基位同时取代的CMCS(N,O-CMCS)的FT-IR图

    Figure  1.  FT-IR spectra of chitosan (CS) and amino substituted carboxymethyl chitosan (N-CMCS), hydroxyl substituted CMCS (O-CMCS), amino and hydroxyl substituted CMCS (N,O-CMCS)

    图  2  O-CMCS(a)、N-CMCS(b)和N,O-CMCS(c) 核磁共振氢谱图

    Figure  2.  1 H-NMR of O-CMCS (a), N-CMCS(b) and N,O-CMCS (c)

    图  3  三种羧甲基壳聚糖结构图[9]

    Figure  3.  Structural diagram of three carboxymethyl chitosans[9]

    图  4  CMCS的透光率

    Figure  4.  Transmittance of CMCS

    图  5  CMCS用量与纸张的干抗张指数(a)和湿抗张指数(b)的关系

    Figure  5.  The relationship between the amount of CMCS and the dry tensile index (a) and the wet tensile index (b) of paper

    图  6  CMCS 用量与纸张(a)撕裂指数和(b)耐破指数的关系

    Figure  6.  The relationship between the amount of CMCS used and (a) the tear index and (b) the burst resistance index of the paper

    图  7  CMCS 用量与纸张透气度的关系

    Figure  7.  The relationship between CMCS dosage and air permeability of paper

    图  8  对照样和添加CMCS纸张的抗菌效果

    Figure  8.  Antimicrobial effect of control samples and addition of CMCS paper

    表  1  不同取代位点CMCS的取代度、溶解度及黏度

    Table  1.   Substitution, solubility and viscosity of CMCS at different substitution sites

    Samples Degree of
    Substitution(DS)
    Water
    Solubility/(g·L-1)
    Viscosity/
    (mPa∙s)
    O-CMCS 0.566 12.44 23.20
    N,O-CMCS 1.196 64.53 15.23
    N-CMCS 1.227 80.00 10.56
    下载: 导出CSV
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出版历程
  • 收稿日期:  2024-01-08
  • 修回日期:  2024-03-01
  • 录用日期:  2024-03-09
  • 网络出版日期:  2024-04-13

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