摘要:
利用低频振荡、冻融法制得果胶/聚乙烯醇复合(CoPP) 水凝胶, 采用红外光谱仪、差示扫描量热仪、X射线衍射仪、扫描电镜, 表征其结构; 观察CoPP水凝胶的溶胀性能, 并探讨扩散模式及溶胀动力学。结果表明: CoPP水凝胶是一种多孔材料、有两个结晶区, 脱水后可再次水合、溶胀; 水分子以菲克扩散模式渗入CoPP水凝胶, CoPP水凝胶的溶胀速率常数、溶胀平衡时的质量溶胀率(197. 38 %～252. 49 %) 、体积溶胀率(241.47 %～308. 93 %), 均大于聚乙烯醇(PVA) 水凝胶。因此, CoPP水凝胶具有溶胀快和溶胀率大等特点, 可减小人工髓核假体植入时的尺寸, 利于微创手术植入。
关键词:
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水凝胶
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溶胀
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果胶
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聚乙烯醇
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人工髓核
Abstract:
The pectin/poly (vinyl alcohol) composite (CoPP) hydrogel was prepared by low f requency oscillation
and freezing-thawing. The structure of CoPP hydrogel was characterized by FTIR, DSC, XRD and SEM, the swelling properties were observed, and the diffusion of water and the swelling dynamics were also discussed. The experimental results show that CoPP hydrogel is porous, and has two kinds of crystal regions. The diffusion characteristic index which water molecule immerses into CoPP hydrogel was near 0. 5, which indicates the diffusion is in Fick model. The swelling velocity constant of CoPP, the swelling ratio of mass (197. 38 %～252. 49 %) and swelling ratio of volume (241. 47 %～308. 93 %) of CoPP at the swelling equilibration were superior to those of poly (vinylalcohol) (PVA) hydrogel. Therefore, the swelling properties of CoPP composite hydrogel are faster and larger, which makes it possible to implant the artificial nucleus pulposus prosthesis in smaller size with the minimally invasive surgery.
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