壳聚糖/氧化石墨烯复合材料研究现状

莫丽娟; 刘莹; 张靖羚; 王子豪

壳聚糖/氧化石墨烯复合材料研究现状

1.
辽宁工程技术大学　材料科学与工程学院, 阜新 123000
2.
辽宁工程技术大学　理学院, 阜新 123000

详细信息

通讯作者:
刘莹，硕士，教授，硕士生导师，研究方向为生物功能材料　E-mail: liuyingfx02@126.com

中图分类号: R318.08; TB332
计量
- 文章访问数: 99
- HTML全文浏览量: 35
- 被引次数: 0
出版历程
- 收稿日期: 2024-05-27
- 修回日期: 2024-07-25
- 录用日期: 2024-08-04
- 网络出版日期: 2024-08-19

Research status of chitosan/graphene oxide composites

1.
College of Materials Science and Engineering, Liaoning Technical University, Fuxin 123000, China
2.
College of Science, Liaoning Technical University, Fuxin 123000, China

摘要

摘要: 壳聚糖(CS)是具有良好生物相容性、可生物降解、无毒、抗菌等优点的天然碱性多糖，但CS材料力学性能较差、遇水易水解。氧化石墨烯(GO)具有较大的比表面积和良好的生物相容性、稳定性，能与其他材料结合制备出性能更优异的复合材料。将CS与GO进行复合，实现优势互补，可以得到兼具优异力学性能、生物活性和生物相容性的壳聚糖/氧化石墨烯(CS/GO)复合材料，CS/GO复合材料可以制备成水凝胶、纳米颗粒、薄膜、多孔材料等形式，这使CS/GO复合材料在环保、食品、医用等领域具有良好的应用前景。本文综述了CS/GO复合材料在药物载体、伤口敷料、组织工程支架、污染物吸附、食品保鲜五个方面的研究现状，并对CS/GO复合材料未来研究方向进行展望。
- 壳聚糖 /
- 氧化石墨烯 /
- 药物载体 /
- 伤口敷料 /
- 组织工程支架 /
- 吸附 /
- 食品保鲜
Abstract: Chitosan (CS) is a natural alkaline polysaccharide with good biocompatibility, biodegradable, non-toxic, antibacterial and other advantages, but CS material has poor mechanical properties and easy hydrolysis in water. Graphene oxide (GO) has a large specific surface area and good biocompatibility, stability, and can be combined with other materials to prepare more excellent properties of composite materials. By combining CS and GO to achieve complementary advantages, chitosan/graphene oxide(CS/GO) composites with excellent mechanical properties, biological activity and biocompatibility can be obtained, CS/GO composites can be prepared into hydrogels, nanoparticles, films, porous materials and other forms, which makes CS/GO composites have good application prospects in environmental protection, food, medical and other fields. In this paper, the research status of CS/GO composites in drug carrier, wound dressing, tissue engineering scaffold, contaminant adsorption, food preservation was reviewed, and the future research direction of CS/GO composites was prospected.
- chitosan /
- graphene oxide /
- drug carrier /
- wound dressing /
- tissue engineering scaffold /
- adsorption /
- food preservation

HTML全文

图 1 甲壳素与壳聚糖(CS)化学结构示意图和氧化石墨烯(GO)结构示意图

Figure 1. Schematic Chemical Structure of Chitin and Chitosan (CS) and Schematic Structure of Graphene Oxide (GO)

下载: 全尺寸图片幻灯片

图 2 CS/GO复合材料的应用及优势

Figure 2. Application and characteristics of CS/GO composites

下载: 全尺寸图片幻灯片

图 3 CS/GO合成示意图

Figure 3. Schematic diagram of CS/GO oxide synthesis

下载: 全尺寸图片幻灯片

图 4 不同形式CS/GO复合材料的扫描电镜图：(a)水凝胶^[27]；(b)纳米颗粒^[28]；(c)薄膜^[29]；(d)多孔材料^[30]

Figure 4. SEM images of different CS/GO composites：(a)Hydrogel^[27]；(b) Nanometer particle^[28]；(c)Thin film^[29]；(d)Porous material^[30]

下载: 全尺寸图片幻灯片

图 5 CS/GO负载甲硝唑药物的制备步骤^[34]

Figure 5. Preparation steps of metronidazole drugs loaded with CS/GO^[34]

下载: 全尺寸图片幻灯片

图 6 神经元在CS/GO支架中的迁移^[45]

Figure 6. Neuron migration in the CS/GO scaffold^[45]

下载: 全尺寸图片幻灯片

表 1 CS/GO复合材料对不同药物的释放效果^[34]

Table 1. Release efficacy of CS/GO composites on different drugs^[34]

Carrier material	Carrier format	Drug	Release time/h
CS/GO	Gel	Ibuprofen	100
	Gel	Sumatriptan	50
	Thin film	Camptothecin	72
	Thin film	Famotidine	12
	Nanometer particle	Metronidazole	84
	Nanometer particle	Folic acid	72

下载: 导出CSV

[1]	刘建新. 壳聚糖材料的制备及其应用研究进展[J]. 纤维素科学与技术, 2023, 31(3): 60-66. LIU Jianxin. Progress on the preparation and application of chitosan materials[J]. Journal of Cellulose Science and Technology, 2023, 31(3): 60-66(in Chinese).
[2]	刘洁, 王娟, 李胜, 等. 壳聚糖的结构、功能及其在农业上的应用研究进展[J]. 包装学报, 2023, 15(4): 21-28. doi: 10.3969/j.issn.1674-7100.2023.04.003 LIU Jie, WANG Juan, LI Sheng, et al. Research progress on structure and function of chitosan and its application in agriculture[J]. Packaging Journal, 2023, 15(4): 21-28(in Chinese). doi: 10.3969/j.issn.1674-7100.2023.04.003
[3]	贾双珠, 李长安, 刘品祯, 等. 壳聚糖的应用研究进展[J]. 精细与专用化学品, 2022, 30(1): 25-30. JIA Shuangzhu, LI Changan, LIU Pinzheng, et al. Research progress of application for chitosan[J]. Fine and Specialty Chemicals, 2022, 30(1): 25-30(in Chinese).
[4]	刘远远. 壳聚糖功能载体构建及其溶菌酶与蛋白酶固定化研究 [D]. 武汉: 华中农业大学, 2020. LIU Yuanyuan. Fabrication of chitosan functional carriers and its application in lysozyme and protease immobilization [D]. Wuhan: Huazhong Agricultural University, 2020(in Chinese).
[5]	AZMANA M, MAHMOOD S, HILLES A R, et al. A review on chitosan and chitosan-based bionanocomposites: Promising material for combatting global issues and its applications[J]. International Journal Of Biological Macromolecules, 2021, 185: 832-848. doi: 10.1016/j.ijbiomac.2021.07.023
[6]	LI L H, ZHOU C R. Tissue Engineering: Scaffolds Derived from Chitosan[J]. Current Organic Chemistry, 2018, 22(7): 708-719. doi: 10.2174/1385272821666171019144752
[7]	MATICA M A, AACHMANN F L, TONDERVIK A, et al. Chitosan as a wound dressing starting material: Antimicrobial properties and mode of action[J]. International Journal Of Molecular Sciences, 2019, 20(23): 5889. doi: 10.3390/ijms20235889
[8]	RAZAQ A, BIBI F, ZHENG X X, et al. Review on Graphene-, Graphene Oxide-, Reduced Graphene Oxide-Based Flexible Composites: From Fabrication to Applications[J]. Materials, 2022, 15(3): 1012. doi: 10.3390/ma15031012
[9]	彭立. 氧化石墨烯复合碳化铌MXene人工角膜支架的构建及应用研究 [D]. 长沙: 中南大学, 2022. PENG Li. Construction and application of graphene oxide and niobium carbide MXene nanocomposite for artificial cornea scaffold [D]. Changsha: Central South University, 2022(in Chinese).
[10]	王婷葛, 葛少华. 氧化石墨烯在生物医学领域方面应用的研究进展[J]. 国际口腔医学杂志, 2017, 44(5): 591-595. doi: 10.7518/gjkq.2017.05.020 WANG Tingge, GE Shaohua. Research progress on the application of graphene oxide in the field of biomedicine[J]. International Journal of Stomatology, 2017, 44(5): 591-595(in Chinese). doi: 10.7518/gjkq.2017.05.020
[11]	吴腾飞, 唐拴虎, 黄建凤, 等. 氧化石墨烯在农业领域的应用研究进展[J]. 广东农业科学, 2023, 50(8): 126-135. WU Tengfei, TANG Shuanhu, HUANG Jianfeng, et al. Research progress on the application of graphene oxide in agriculture[J]. Guangdong. Agricultural Sciences, 2023, 50(8): 126-135(in Chinese).
[12]	张笑娟, 魏琦峰, 任秀莲. 氧化石墨烯的制备方法、结构、性质及应用研究进展[J]. 应用化工, 2022, 51(7): 2106-2112. doi: 10.3969/j.issn.1671-3206.2022.07.049 ZHANG Xiaojuan, WEI Qifeng, REN Xxiulian. Research progress of graphene oxide preparation methods, structure, properties and applications[J]. Applied Chemical Industry, 2022, 51(7): 2106-2112(in Chinese). doi: 10.3969/j.issn.1671-3206.2022.07.049
[13]	张利芳. 氧化石墨烯/壳聚糖水凝胶对内皮祖细胞成血管功能的影响 [D]. 广州: 南方医科大学, 2021. ZHANG Lifang. Angiogenic effect of graphene oxide/chitosan hydrogel on endothelial progenitor cells [D]. Guangzhou: Southern Medical University, 2021(in Chinese).
[14]	张文婧. 壳聚糖-氧化石墨烯的制备及其抗真菌性能的研究 [D]. 秦皇岛: 河北科技师范学院, 2023. ZHANG Wenjing. Preparation, characterization and antifungal properties of chitosan-graphene oxide [D]. Qinhuangdao: Hebei Normal University Of Science & Technology, 2023(in Chinese).
[15]	李亚峰, 侯瑞博. 壳聚糖/氧化石墨烯复合材料水处理技术研究进展[J]. 水处理技术, 2023, 49(6): 1-7+14. LI Yafeng, HOU Ruibo. Research progress on preparation of chitosan/graphene oxide composites and its application in wastewater treatment[J]. Technology of Water Treatment, 2023, 49(6): 1-7+14(in Chinese).
[16]	黄倩, 郝丽英, 贺龙龙, 等. 氧化石墨烯/壳聚糖复合涂层影响成骨细胞的生物学行为[J]. 中国组织工程研究, 2023, 27(34): 5430-5435. HUANG Qian, HAO Liying, HE Longlong, et al. Graphene oxide-chitosan composite coating affects the biological behavior of osteoblasts[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(34): 5430-5435(in Chinese).
[17]	POLITAEVA N, YAKOVLEV A, YAKOVLEVA E, et al. Graphene Oxide-Chitosan Composites for Water Treatment from Copper Cations[J]. Water, 2022, 14(9): 1430. doi: 10.3390/w14091430
[18]	KAHYA N, ERIM F B. Graphene oxide/ chitosan-based composite materials as adsorbents in dye removal[J]. Chemical Engineering Communications, 2022, 209(12): 1711-1726. doi: 10.1080/00986445.2021.1986700
[19]	CROISIER F, JÉRÔME C. Chitosan-based biomaterials for tissue engineering[J]. European Polymer Journal, 2013, 49(4): 780-794. doi: 10.1016/j.eurpolymj.2012.12.009
[20]	JING X, MI H Y, NAPIWOCKI B N, et al. Mussel-inspired electroactive chitosan/graphene oxide composite hydrogel with rapid self-healing and recovery behavior for tissue engineering[J]. Carbon, 2017, 125: 557-570. doi: 10.1016/j.carbon.2017.09.071
[21]	WAHID F, ZHAO X J, JIA S R, et al. Nanocomposite hydrogels as multifunctional systems for biomedical applications: Current state and perspectives[J]. Composites Part B: Engineering, 2020, 200: 108208. doi: 10.1016/j.compositesb.2020.108208
[22]	PAN Y Z, WU T F, BAO H Q, et al. Green fabrication of chitosan films reinforced with parallel aligned graphene oxide[J]. Carbohydrate Polymers, 2011, 83(4): 1908-1915. doi: 10.1016/j.carbpol.2010.10.054
[23]	HAN D L, YAN L F, CHEN W F. Preparation of chitosan/graphene oxide composite film with enhanced mechanical strength in the wet state[J]. Carbohydrate Polymers, 2011, 83(2): 653-658. doi: 10.1016/j.carbpol.2010.08.038
[24]	吕生华, 李莹杨, 杨文强, 等. 氧化石墨烯/壳聚糖生物复合材料的制备及应用研究进展[J]. 材料工程, 2016, 44(10): 119-128. doi: 10.11868/j.issn.1001-4381.2016.10.017 LV Shenghua, LI Yinyang, YANG Wenqiang, et al. Research Progress on Preparatin and Aplication of Graphene 0xide/Chitosan Biocomposites[J]. Journal of Materials Engineering, 2016, 44(10): 119-128(in Chinese). doi: 10.11868/j.issn.1001-4381.2016.10.017
[25]	姚庆达, 梁永贤, 王小卓, 等. GO/CS的结构、性能及其在水处理中的应用研究进展[J]. 材料导报, 2022, 36(4): 36-48. doi: 10.11896/cldb.20110041 YAO Qingda, LIANG Yongxian, WANG Xiaozhuo, et al. Structure and Performance of Graphene Orie/Chitoan Composite and ts Aplcation in Water Treatment: a Review[J]. Materials Reports, 2022, 36(4): 36-48(in Chinese). doi: 10.11896/cldb.20110041
[26]	刘相. 氧化石墨烯复合气凝胶的制备及其性能研究 [D]. 西安: 陕西科技大学, 2022. LIU Xiang. Preparation and Properties of Graphene Oxide Composite Aerogels [D]. Xian: Shaanxi University of Science&Technology, 2022(in Chinese).
[27]	FENG W J, WANG Z K. Shear-thinning and self-healing chitosan-graphene oxide hydrogel for hemostasis and wound healing[J]. Carbohydrate Polymers, 2022, 294: 119824. doi: 10.1016/j.carbpol.2022.119824
[28]	POORESMAEIL M, ASL E A, NAMAZI H. Simple fabrication of biocompatible chitosan/graphene oxide microspheres for pH-controlled amoxicillin delivery[J]. European Polymer Journal, 2021, 159: 110706. doi: 10.1016/j.eurpolymj.2021.110706
[29]	DE PAIVA C A, VILVERT J C, DE MENEZES F L G, et al. Extended shelf life of melons using chitosan and graphene oxide-based biodegradable bags[J]. Journal Of Food Processing And Preservation, 2020, 44(11): e14871.
[30]	刘杨, 张中勋, 伍铭慧, 等. 氧化石墨烯修饰壳聚糖基支架的构建及其作为骨修复材料的研究[J]. 常州大学学报(自然科学版), 2018, 30(1): 87-92. LIU Yang, ZHANG Zhongxun, WU Minghui, et al. Preparation of chitosan scaffold modified by graphene oxide and its potential applications as bone repair material[J]. Journal of Changzhou University(Natural Science Edition), 2018, 30(1): 87-92(in Chinese).
[31]	RAO Z Q, GE H Y, LIU L L, et al. Carboxymethyl cellulose modified graphene oxide as pH-sensitive drug delivery system[J]. International Journal Of Biol Ogical Macromolecules, 2018, 107: 1184-1192. doi: 10.1016/j.ijbiomac.2017.09.096
[32]	PRAMANIK N, RANGANATHAN S, RAO S, et al. A Composite of Hyaluronic Acid-Modified Graphene Oxide and Iron Oxide Nanoparticles for Targeted Drug Delivery and Magnetothermal Therapy[J]. Acs Omega, 2019, 4(5): 9284-9293. doi: 10.1021/acsomega.9b00870
[33]	李旭蕊. 羟丁基壳聚糖/氧化石墨烯复合温敏水凝胶的制备及直肠给药研究 [D]. 沈阳: 辽宁大学, 2022. LI Xurui. Preparation and rectal administration of hydroxybutyl chitosan/ graphene oxide composite thermosensitive hydrogel [D]. Shenyang: Liaoning University, 2022(in Chinese).
[34]	KUMAR G, CHAUDHARY K, MOGHA N K, et al. Extended Release of Metronidazole Drug Using Chitosan/Graphene Oxide Bionanocomposite Beads as the Drug Carrier[J]. Ace Omega, 2021, 6(31): 20433-20444. doi: 10.1021/acsomega.1c02422
[35]	EROL Ü H, GÜNCÜM E, ISIKLAN N. Development of chitosan-graphene oxide blend nanoparticles for controlled flubiprofen delivery[J]. International Journal Of Biological Macromolecules, 2023, 246: 125627. doi: 10.1016/j.ijbiomac.2023.125627
[36]	SUN M K, REN Z, WEI T T, et al. Preparation, characterization and immune activity of Codonopsis pilosula polysaccharide loaded in chitosan-graphene oxide[J]. International Journal Of Biological Macromolecules, 2022, 221: 1466-1475. doi: 10.1016/j.ijbiomac.2022.08.209
[37]	MONA A, MARZIEH M, SEYED M T, et al. Fabrication of aptamer decorated dextran coated nano-graphene oxide for targeted drug delivery[J]. Carbohydrate Polymers, 2017, 155: 218-229. doi: 10.1016/j.carbpol.2016.08.046
[38]	CAO S J, XU G, LI Q J, et al. Double crosslinking chitosan sponge with antibacterial and hemostatic properties for accelerating wound repair[J]. Composites Part B-Engineering, 2022, 234: 109746. doi: 10.1016/j.compositesb.2022.109746
[39]	徐聪聪. 氧化石墨烯-壳聚糖复合止血海绵的制备及性能研究 [D]. 北京: 北京化工大学, 2020. XU Congcong. Research on preparation and properties of graphene 0xide-chitosan composite sponge [D]. Beijing: Beijing University of Chemical Technology, 2020(in Chinese).
[40]	LIN X W, SHEN Y J, WANG L D. Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan-Graphene Oxide Hemostatic Sponge[J]. Nanomaterials, 2021, 11(11): 2879. doi: 10.3390/nano11112879
[41]	DU F L, WEN J A, LIU F, et al. Hydrophilic chitosan/graphene oxide composite sponge for rapid hemostasis and non-rebleeding removal[J]. Carbohydrate Polymers, 2023, 316: 121058. doi: 10.1016/j.carbpol.2023.121058
[42]	CROITORU A M, FICAI A, FICAI D, et al. Chitosan/Graphene Oxide Nanocomposite Membranes as Adsorbents with Applications in Water Purification[J]. MATERIALS, 2020, 13(7): 1687. doi: 10.3390/ma13071687
[43]	YANG J, LONG T, HE N F, et al. Fabrication of a chitosan/bioglass three-dimensional porous scaffold for bone tissue engineering applications[J]. Journal Of Materials Chemistry B, 2014, 2(38): 6611-6618. doi: 10.1039/C4TB00940A
[44]	JING X, MI H Y, NAPIWOCKI B N, et al. Mussel-inspired electroactive chitosan/ graphene oxide composite hydrogel with rapid self-healing and recovery behavior for tissue engineering[J]. Carbon, 2017, 125: 557-570. doi: 10.1016/j.carbon.2017.09.071
[45]	YANG B, WANG P B, MU N, et al. Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats[J]. Neural Regeneration Research, 2021, 16(9): 1829-2835. doi: 10.4103/1673-5374.306095
[46]	WONG S H M, LIM S S, TIONG T J, et al. Preliminary In Vitro Evaluation of Chitosan-Graphene Oxide Scaffolds on Osteoblastic Adhesion, Proliferation, and Early Differentiation[J]. International Journal Of Molecular Sciences, 2020, 21(15): 5202. doi: 10.3390/ijms21155202
[47]	SHAMEKHI M A, MIRZADEH H, MAHDAVI H, et al. Graphene oxide containing chitosan scaffolds for cartilage tissue engineering[J]. International Journal Of Biological Macromolecules, 2019, 127: 396-405. doi: 10.1016/j.ijbiomac.2019.01.020
[48]	JIANG L L, CHEN D Y, WANG Z, et al. Preparation of an Electrically Conductive Graphene Oxide/Chitosan Scaffold for Cardiac Tissue Engineering[J]. Applied Biochemistry And Biotechnology, 2019, 188(4): 952-964. doi: 10.1007/s12010-019-02967-6
[49]	周国萍, 康成, 王士凡, 等. 纳米复合高分子重金属离子吸附材料的研究进展[J]. 水处理技术, 2021, 47(8): 26-31. ZHOU Guoping, KANG Cheng, WANG Shifan, et al. Research progress on adsorption of heavy metal lons materials based on nanocomposite polymer[J]. Technology of Water Treatment, 2021, 47(8): 26-31(in Chinese).
[50]	蒋达, 吴雪兰, 龙红明, 等. 碳基材料表面改性及吸附性能的研究进展[J]. 应用化工, 2023, 52(7): 2178-2183. doi: 10.3969/j.issn.1671-3206.2023.07.045 JIANG Da, WU Xuelan, LONG Hongming, et al. Research progress on surface modification and adsorption properties of carbon-based materials[J]. Applied Chemical Industry, 2023, 52(7): 2178-2183(in Chinese). doi: 10.3969/j.issn.1671-3206.2023.07.045
[51]	霍香岩, 许嘉兴, 严泰森, 等. 吸附式空气取水物理吸附材料研究进展[J]. 科学通报, 2023, 68(11): 1392-1405. doi: 10.1360/TB-2022-0939 HUO Xiangyan, XU Jiaxing, YAN Taisen, et al. Research status of physical sorbents for sorption-based atmospheric water harvesting[J]. Chinese Science Bulletin, 2023, 68(11): 1392-1405(in Chinese). doi: 10.1360/TB-2022-0939
[52]	李亚峰, 侯瑞博. 壳聚糖/氧化石墨烯复合材料水处理技术研究进展[J]. 水处理技术, 2023, 49(6): 1-7+14. LI Yafeng, HOU Ruibo. Research progress on preparation of chitosan/graphene oxide composites and its application in wastewater treatment[J]. Technology of Water Treatment, 2023, 49(6): 1-7+14(in Chinese).
[53]	VO T S, VO T T B C, SUK J W, et al. Recycling performance of graphene oxide-chitosan hybrid hydrogels for removal of cationic and anionic dyes[J]. Nano Convergence, 2020, 7(1): 4. doi: 10.1186/s40580-019-0215-0
[54]	郭永梅, 邱宇. 聚丙烯酸/氧化石墨烯-壳聚糖复合膜的制备及其对染料的吸附分离[J]. 高分子通报, 2023, 36(12): 1725-1733. GUO Yongmei, QIU Yu. Preparation of Poly(acrylic acid)/Graphene Oxide-Chitosan Composite Membrane and the Adsorption and Separation on Dyes[J]. Polymer Bulletin, 2023, 36(12): 1725-1733(in Chinese).
[55]	FAHEEM S, SOHAIL M, HUSSAIN F, et al. Synthesis and Characterization of Chitosan and Graphene Oxide to Form a Nano-Composite Hydrogel for the Removal of Heavy Metal Ions[J]. Journal Of Water Chemistry And Technology, 2021, 43(1): 22-28. doi: 10.3103/S1063455X21010070
[56]	龚育, 孔亚飞, 马真真, 等. 氧化石墨烯/壳聚糖复合微球的制备及其对铌的吸附性能[J]. 冶金分析, 2017, 37(8): 15-20. GONG Yu, KONG Yafei, MA Zhenzhen, et al. Preparation of graphene oxide/chitosan composite beads and its adsorption performance for nibium[J]. Metallurgical Analysis, 2017, 37(8): 15-20 (in Chinese).
[57]	尹爽, 陈沛嘉, 余维粤, 等. 可生物降解聚酯抗菌功能化研究进展[J]. 塑料, 2023, 52(5): 128-133+161. YIN Shuang, CHEN Peijia, YU Weiyue, et al. Recent progress on antibacterial functionalization of biodegradable polyester[J]. Plastics, 2023, 52(5): 128-133+161(in Chinese).
[58]	WROŃSKA N, ANOUAR A, El Achaby M, et al. Chitosan-Functionalized Graphene Nanocomposite Films: Interfacial Interplay and Biological Activity[J]. Materials, 2020, 13(4): 998. doi: 10.3390/ma13040998
[59]	HAMMI N, WROŃSKA N, KATIR N, et al. Supramolecular Chemistry-Driven Preparation of Nanostructured, Transformable, and Biologically Active Chitosan-Clustered Single, Binary, and Ternary Metal Oxide Bioplastics[J]. ACS Appl Bio Mater, 2019, 2(1): 61-69. doi: 10.1021/acsabm.8b00306
[60]	刘括, 叶肖杏, 张培, 等. 氧化石墨烯/壳聚糖复合保鲜剂对火龙果保鲜性能的影响[J]. 玉林师范学院学报, 2019, 40(5): 77-83. LIU Kuo, YE Xiaoxing, ZHANG Pei, et al. Study on the preservative properties of pitaya by graphene oxide/chitosan compound preservative[J]. Journal of Yulin Normal University, 2019, 40(5): 77-83(in Chinese).
[61]	刘括, 王成国, 聂国朝. 氧化石墨烯-壳聚糖复合保鲜剂对“六月红”荔枝保鲜性能的研究[J]. 食品科技, 2019, 44(7): 62-67. LIU Kuo, WANG Chengguo, NIE Guochao. The preservative properties of "June red" litchi by graphene oxidechitosan compound preservative[J]. Food Science and Technology, 2019, 44(7): 62-67(in Chinese).
[62]	施昌谷, 邵明聪, 李文娟, 等. 壳聚糖/氧化石墨烯复合涂膜食品包装纸的研究[J]. 中国食品学报, 2019, 19(7): 192-200. SHI Changgu, SHAO Mingcong, LI Wenjuan, et al. Studies on food cellulose paper coated by chitosan/graphene oxide[J]. Journal of Chinese Institute of Food Science and Technology, 2019, 19(7): 192-200(in Chinese).